Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity

QR Code

Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity

In an effort to develop new antibacterial drugs, some novel bisindolylmethane derivatives containing Schiff base moieties were prepared and screened for their antibacterial activity. The synthesis of the bisindolylmethane Schiff base derivatives 3-26 was carried out in three steps. First, the nitro...

Full description

Bibliographic Details
Published in:	Molecules
Main Author:	Imran S.; Taha M.; Ismail N.H.; Khan K.M.; Naz F.; Hussain M.; Tauseef S.
Format:	Article
Language:	English
Published:	MDPI AG 2014
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906674651&doi=10.3390%2fmolecules190811722&partnerID=40&md5=982b7651461e66d9046852359b5c39fa

Similar Items

Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies
by: Imran S.; Taha M.; Ismail N.H.; Fayyaz S.; Khan K.M.; Choudhary M.I.
Published: (2016)

Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor
by: Imran S.; Taha M.; Ismail N.H.; Fayyaz S.; Khan K.M.; Choudhary M.I.
Published: (2015)

Synthesis and antiurease & antioxidant activities of bis-Schiff bases of isophthalaldehyde
by: Rahim F.; Waseeq-Ur-Rehamn; Shehzad M.; Khan A.; Taha M.; Abid O.U.R.; Quereshi M.T.; Tauseef I.; Rehman W.
Published: (2016)

Identification of bisindolylmethane-hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT, and in silico SAR intimations
by: Taha M.; Ismail N.H.; Imran S.; Anouar E.H.; Ali M.; Jamil W.; Uddin N.; Kashif S.M.
Published: (2016)

A review of bisindolylmethane as an important scaffold for drug discovery
by: Imran S.; Taha M.; Ismail N.H.
Published: (2015)

Acylhydrazide schiff bases: Synthesis and antiglycation activity
by: Khan K.M.; Taha M.; Rahim F.; Fakhri M.I.; Jamil W.; Khan M.; Rasheed S.; Karim A.; Perveen S.; Choudhary M.I.
Published: (2013)

Bisindolylmethane thiosemicarbazides as potential inhibitors of urease: Synthesis and molecular modeling studies
by: Taha M.; Ullah H.; Al Muqarrabun L.M.R.; Khan M.N.; Rahim F.; Ahmat N.; Javid M.T.; Ali M.; Khan K.M.
Published: (2018)

Aryl-oxadiazole Schiff bases: Synthesis, α-glucosidase in vitro inhibitory activity and their in silico studies
by: Ullah H.; Rahim F.; Taha M.; Hussain R.; Tabassum N.; Wadood A.; Nawaz M.; Mosaddik A.; Imran S.; Wahab Z.; Miana G.A.; Kanwal; Khan K.M.
Published: (2020)

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives
by: Taha M.; Noreen T.; Imran S.; Nawaz F.; Chigurupati S.; Selvaraj M.; Rahim F.; Hadiani Ismail N.; Kumar A.; Mosaddik A.; Alghamdi A.M.; Abdulrahman nasser alqahtani Y.; Abdulrahman nasser alqahtani A.
Published: (2019)

Synthesis, in vitro thymidine phosphorylase inhibitory activity and molecular docking study of novel pyridine-derived bis-oxadiazole bearing bis-schiff base derivatives
by: Hussain R.; Rehman W.; Rahim F.; Khan S.; Alanazi A.S.; Alanazi M.M.; Rasheed L.; Khan Y.; Adnan. Ali. Shah S.; Taha M.
Published: (2023)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
by: Taha M.; Alshamrani F.J.; Rahim F.; Hayat S.; Ullah H.; Zaman K.; Imran S.; Khan K.M.; Naz F.
Published: (2019)

Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents
by: Taha M.; Sain A.A.; Ali M.; Anouar E.H.; Rahim F.; Ismail N.H.; Adenan M.I.; Imran S.; Al-Harrasi A.; Nawaz F.; Iqbal N.; Khan K.M.
Published: (2020)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood N.; Hussain R.; Khan S.; Rahim F.; Mumtaz S.; Taha M.; Ur Rahman Abid O.; Iqbal T.; Adnan Ali Shah S.; Omar Al Wesabi E.; Magam S.M.
Published: (2024)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood, et al.
Published: (2024)

Cadmium(II) Schiff base Complex Containing 5-Fluoroisatin Moiety: Synthesis, Characterization, Antibacterial Activity and Structural Studies
by: Abdul Manan M.A.F.; Cordes D.B.
Published: (2022)

Novel hydrazone schiff’s base derivatives of polyhydroquinoline: synthesis, in vitro prolyl oligopeptidase inhibitory activity and their Molecular docking study
by: Talab F.; Alam A.; Zainab; Ullah S.; Elhenawy A.A.; Shah S.A.A.; Ali M.; Halim S.A.; Khan A.; Latif A.; Al-Harrasi A.; Ahmad M.
Published: (2024)

Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
by: Taha M.; Ismail N.H.; Lalani S.; Fatmi M.Q.; Atia-Tul-Wahab; Siddiqui S.; Khan K.M.; Imran S.; Choudhary M.I.
Published: (2015)

Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
by: Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
Published: (2014)

Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases
by: Rahim F.; Ullah H.; Taha M.; Wadood A.; Javed M.T.; Rehman W.; Nawaz M.; Ashraf M.; Ali M.; Sajid M.; Ali F.; Khan M.N.; Khan K.M.
Published: (2016)

Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors
by: Taha M.; Sultan S.; Nuzar H.A.; Rahim F.; Imran S.; Ismail N.H.; Naz H.; Ullah H.
Published: (2016)

Synthesis of novel benzohydrazone-oxadiazole hybrids as β-glucuronidase inhibitors and molecular modeling studies
by: Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rahim A.; Ali M.; Siddiqui S.; Rahim F.; Khan K.M.
Published: (2015)

Synthesis, anti-diabetic and in silico QSAR analysis of flavone hydrazide Schiff base derivatives
by: Jamil W.; Shaikh J.; Yousuf M.; Taha M.; Khan K.M.; Shah S.A.A.
Published: (2022)

Structural Characterization, DFT, Hirshfeld Surface Analysis and Antibacterial Activity of a Schiff Base Derived from Cyclohexanediamine
by: Nasaruddin N.H.; Ahmad S.N.; Sirat S.S.; Wai T.K.; Zakaria N.A.; Bahron H.
Published: (2021)

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies
by: Taha M.; Ismail N.H.; Khan A.; Shah S.A.A.; Anwar A.; Halim S.A.; Fatmi M.Q.; Imran S.; Rahim F.; Khan K.M.
Published: (2015)

Synthesis of Benzofuran–based Schiff bases as anti-diabetic compounds and their molecular docking studies
by: Adalat B.; Rahim F.; Taha M.; Hayat S.; Iqbal N.; Ali Z.; Shah S.A.A.; Wadood A.; Rehman A.U.; Khan K.M.
Published: (2022)

Synthesis of novel inhibitors of β-glucuronidase based on the benzothiazole skeleton and their molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rahim F.
Published: (2016)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
by: Rahim F.; Malik F.; Ullah H.; Wadood A.; Khan F.; Javid M.T.; Taha M.; Rehman W.; Ur Rehman A.; Khan K.M.
Published: (2015)

Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach
by: Gul S.; Alam A.; Zainab; Assad M.; Elhenawy A.A.; Islam M.S.; Shah S.A.A.; Parveen Z.; Shah T.A.; Ahmad M.
Published: (2024)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar A.; Khan I.U.; Nabi M.; Ullah H.; Iqbal N.; Zeb B.; Hussain A.; Khan D.; Rab A.; Junaid S.M.; Taha M.; Shah S.A.A.; Rahim F.
Published: (2024)

Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors
by: Taha M.; Imran S.; Rahim F.; Wadood A.; Khan K.M.
Published: (2018)

Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach
by: Gul, et al.
Published: (2024)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar, et al.
Published: (2024)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: Taha, et al.
Published: (2024)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: Taha M.; Gilani S.J.; Kazmi I.; Rahim F.; Adalat B.; Ullah H.; Nawaz F.; Wadood A.; Ali Z.; Shah S.A.A.; Khan K.M.
Published: (2024)

Synthesis, in vitro β-glucuronidase inhibitory activity and in silico studies of novel (E)-4-Aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazoles
by: Salar U.; Khan K.M.; Syed S.; Taha M.; Ali F.; Ismail N.H.; Perveen S.; Wadood A.; Ghufran M.
Published: (2017)

Structural characterization, theoretical and antibacterial study of a V-shaped, cyclohexane bridged ONNO Schiff base
by: Nasaruddin N.H.; Ahmad S.N.; Sirat S.S.; Tan K.W.; Zakaria N.A.; Kurniawan C.; Bahron H.
Published: (2022)

Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine
by: Nasaruddin N.H.; Ahmad S.N.; Sirat S.S.; Tan K.W.; Zakaria N.A.; Mohamad Nazam S.S.; Rahman N.M.M.A.; Mohd Yusof N.S.; Bahron H.
Published: (2022)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
by: Rahim F.; Zaman K.; Taha M.; Ullah H.; Ghufran M.; Wadood A.; Rehman W.; Uddin N.; Shah S.A.A.; Sajid M.; Nawaz F.; Khan K.M.
Published: (2020)

Antioxidant properties of phenolic Schiff bases: Structure-activity relationship and mechanism of action
by: Anouar E.H.; Raweh S.; Bayach I.; Taha M.; Baharudin M.S.; Di Meo F.; Hasan M.H.; Adam A.; Ismail N.H.; Weber J.-F.F.; Trouillas P.
Published: (2013)

Synthesis of novel disulfide and sulfone hybrid scaffolds as potent β-glucuronidase inhibitor
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Al Muqarrabin L.M.R.; Zaki H.M.; Ahmat N.; Nasir A.; Khan F.
Published: (2016)