Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides

Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides

A series of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides (1-21) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were screened for their in vitro antimicrobial and anticancer potentials. The synthesized compounds displayed hig...

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Published in:Arabian Journal of Chemistry
Main Author: Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
Format: Article
Language:English
Published: Elsevier 2014
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905580114&doi=10.1016%2fj.arabjc.2013.05.010&partnerID=40&md5=344cb7e9d656c1359baf1f37bf84c90c
id 2-s2.0-84905580114
spelling 2-s2.0-84905580114
Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
2014
Arabian Journal of Chemistry
7
4
10.1016/j.arabjc.2013.05.010
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905580114&doi=10.1016%2fj.arabjc.2013.05.010&partnerID=40&md5=344cb7e9d656c1359baf1f37bf84c90c
A series of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides (1-21) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were screened for their in vitro antimicrobial and anticancer potentials. The synthesized compounds displayed higher antifungal potential as compared to antibacterial potential. Besides having good antifungal potential, the synthesized compounds were having appreciable anticancer potential and a number of compounds displayed higher anticancer potential than the standard drug, carboplatin. The results of QSAR studies demonstrated the importance of steric parameter, molar refractivity (MR), topological parameters, third order molecular connectivity index (3χ), Kier's first order shape index (κ1) in describing the antimicrobial activity of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides. © 2013 .
Elsevier
18785352
English
Article
All Open Access; Gold Open Access
author Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
spellingShingle Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
author_facet Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
author_sort Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
title Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
title_short Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
title_full Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
title_fullStr Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
title_full_unstemmed Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
title_sort Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
publishDate 2014
container_title Arabian Journal of Chemistry
container_volume 7
container_issue 4
doi_str_mv 10.1016/j.arabjc.2013.05.010
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905580114&doi=10.1016%2fj.arabjc.2013.05.010&partnerID=40&md5=344cb7e9d656c1359baf1f37bf84c90c
description A series of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides (1-21) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were screened for their in vitro antimicrobial and anticancer potentials. The synthesized compounds displayed higher antifungal potential as compared to antibacterial potential. Besides having good antifungal potential, the synthesized compounds were having appreciable anticancer potential and a number of compounds displayed higher anticancer potential than the standard drug, carboplatin. The results of QSAR studies demonstrated the importance of steric parameter, molar refractivity (MR), topological parameters, third order molecular connectivity index (3χ), Kier's first order shape index (κ1) in describing the antimicrobial activity of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides. © 2013 .
publisher Elsevier
issn 18785352
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
_version_ 1809678488480776192

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