Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors
Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 μM), 5 (IC50= 9.47 ± 0.16 μM), 7 (IC50 = 14.7 ± 0.19 μM), 8 (IC50 = 15.4 ± 1.56 μM), 11 (IC50 = 19.6 ± 0.62 μM), 12 (IC50 = 30.7 ± 1...
| Published in: | Molecules |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904816945&doi=10.3390%2fmolecules19078788&partnerID=40&md5=4ea215c3b1b56d6b5540b58789414447 |
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2-s2.0-84904816945 |
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2-s2.0-84904816945 Jamil W.; Perveen S.; Shah S.A.A.; Taha M.; Ismail N.H.; Perveen S.; Ambreen N.; Khan K.M.; Choudhary M.I. Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors 2014 Molecules 19 7 10.3390/molecules19078788 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904816945&doi=10.3390%2fmolecules19078788&partnerID=40&md5=4ea215c3b1b56d6b5540b58789414447 Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 μM), 5 (IC50= 9.47 ± 0.16 μM), 7 (IC50 = 14.7 ± 0.19 μM), 8 (IC50 = 15.4 ± 1.56 μM), 11 (IC50 = 19.6 ± 0.62 μM), 12 (IC50 = 30.7 ± 1.49 μM), 15 (IC50 = 12.0 ± 0.16 μM), 21 (IC50 = 13.7 ± 0.40 μM) and 22 (IC50 = 22.0 ± 0.14 μM) showed promising β-glucuronidase inhibition activity, better than the standard (D-saccharic acid-1,4-lactone, IC50 = 48.4 ± 1.25 μM). MDPI AG 14203049 English Article All Open Access; Gold Open Access; Green Open Access |
| author |
Jamil W.; Perveen S.; Shah S.A.A.; Taha M.; Ismail N.H.; Perveen S.; Ambreen N.; Khan K.M.; Choudhary M.I. |
| spellingShingle |
Jamil W.; Perveen S.; Shah S.A.A.; Taha M.; Ismail N.H.; Perveen S.; Ambreen N.; Khan K.M.; Choudhary M.I. Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors |
| author_facet |
Jamil W.; Perveen S.; Shah S.A.A.; Taha M.; Ismail N.H.; Perveen S.; Ambreen N.; Khan K.M.; Choudhary M.I. |
| author_sort |
Jamil W.; Perveen S.; Shah S.A.A.; Taha M.; Ismail N.H.; Perveen S.; Ambreen N.; Khan K.M.; Choudhary M.I. |
| title |
Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors |
| title_short |
Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors |
| title_full |
Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors |
| title_fullStr |
Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors |
| title_full_unstemmed |
Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors |
| title_sort |
Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors |
| publishDate |
2014 |
| container_title |
Molecules |
| container_volume |
19 |
| container_issue |
7 |
| doi_str_mv |
10.3390/molecules19078788 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904816945&doi=10.3390%2fmolecules19078788&partnerID=40&md5=4ea215c3b1b56d6b5540b58789414447 |
| description |
Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 μM), 5 (IC50= 9.47 ± 0.16 μM), 7 (IC50 = 14.7 ± 0.19 μM), 8 (IC50 = 15.4 ± 1.56 μM), 11 (IC50 = 19.6 ± 0.62 μM), 12 (IC50 = 30.7 ± 1.49 μM), 15 (IC50 = 12.0 ± 0.16 μM), 21 (IC50 = 13.7 ± 0.40 μM) and 22 (IC50 = 22.0 ± 0.14 μM) showed promising β-glucuronidase inhibition activity, better than the standard (D-saccharic acid-1,4-lactone, IC50 = 48.4 ± 1.25 μM). |
| publisher |
MDPI AG |
| issn |
14203049 |
| language |
English |
| format |
Article |
| accesstype |
All Open Access; Gold Open Access; Green Open Access |
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1820775478776037376 |