Wound healing analysis of pectin/carboxymethyl cellulose/microfibrillated cellulose based composite scaffolds

• Published in: Materials Letters
• Main Author: Ninan N.; Muthiah M.; Park I.-K.; Kalarikkal N.; Elain A.; Wui Wong T.; Thomas S.; Grohens Y.
• Format: Article
• Language: English
• Published: Elsevier 2014
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903640058&doi=10.1016%2fj.matlet.2014.06.056&partnerID=40&md5=2d5f836605152e7f1a1f5a56920e7c0c

In our previous study, we have synthesised pectin/carboxymethyl cellulose/microfibrillated cellulose composite scaffolds by lyophilisation and investigated its morphological, mechanical, thermal properties and tested their cytotoxicity. In this work, we explored the wound healing ability of pectin/carboxymethyl cellulose/microfibrillated cellulose based composite scaffolds. The pore size of the prepared scaffold was ideal for the growth of dermal fibroblasts. The in vivo studies conducted on Sprague Dawley rats showed that it could promote skin regeneration within ten days. The histological examination revealed excellent collagen deposition and complete re-epithelialisation in case of rats treated with composite, confirming its potential as excellent wound dressing material. © 2014 Elsevier B.V.