A novel rare copy number variant of the ABCF1 gene identified among dengue fever patients from Peninsular Malaysia

• Published in: Genetics and Molecular Research
• Main Author: Hoh B.P.; Sam S.S.; Umi S.H.; Mahiran M.; Nik Khairudin N.Y.; Rafidah Hanim S.; AbuBakar S.
• Format: Article
• Language: English
• Published: Fundacao de Pesquisas Cientificas de Ribeirao Preto 2014
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897476394&doi=10.4238%2f2014.February.19.9&partnerID=40&md5=64f739f6ca3ae47459194ece9449e4a2
• ISSN: 16765680
• DOI: 10.4238/2014.February.19.9

Copy number variation (CNV) is a form of genetic variation in addition to single nucleotide polymorphisms. The significance of CNV in the manifestation of a number of diseases is only recently receiving considerable attention. We genotyped 163 dengue patients from Peninsular Malaysia for genes possibly linked to dengue infection using quantitative real-time PCR. Here, we report a serendipitous discovery of a novel rare CNV of the ABCF1 gene among the dengue patients. Among these patients, two had a gain of 1 copy (CN = 3) and one had lost 1 copy (CN = 1), indicating that a rare CNV of the ABCF1 gene was detected among dengue patients from Peninsular Malaysia. Although the gene is suspected to regulate inflammatory responses and pathogen-induced cytokine storm, its relevance to dengue requires further investigation. © FUNPEC-RP.