The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach

QR Code

The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach

Background: Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in metabolomics, early detection and personalised treatment are possible. Methods: Metabolomic profile of 21 ALL patients treated with 6...

Full description

Bibliographic Details
Published in:	Clinical Biochemistry
Main Author:	Bannur Z.; Teh L.K.; Hennesy T.; Rosli W.R.W.; Mohamad N.; Nasir A.; Ankathil R.; Zakaria Z.A.; Baba A.; Salleh M.Z.
Format:	Article
Language:	English
Published:	Elsevier Inc. 2014
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897111004&doi=10.1016%2fj.clinbiochem.2014.02.013&partnerID=40&md5=23dfee2a0fcc552213b9497e3d6c52ca

Similar Items

Differential metabolomic pathway analysis in Malaysian childhood acute lymphoblastic leukemia patients treated with high-dose methotrexate
by: Razali R.H.; Teh L.K.; Salleh M.Z.; Teh K.H.; Mohd Ibrahim H.
Published: (2024)

Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine
by: Wan Rosalina W.R.; Teh L.K.; Mohamad N.; Nasir A.; Yusoff R.; Baba A.A.; Salleh M.Z.
Published: (2012)

Metabolomics Profiling of Age-Associated Metabolites in Malay Population
by: Tan J.K.; Zakaria S.N.A.; Gunasekaran G.; Abdul Sani N.F.; Nasaruddin M.L.; Jaafar F.; Abu Bakar Z.H.; Amir Hamzah A.I.Z.; Nor Aripin K.N.; Mohd Rani M.D.; Noh N.A.; Damanhuri H.A.; Mazlan M.; Makpol S.; Wan Ngah W.Z.
Published: (2023)

Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
by: Lim S.C.; Johari B.; Tang S.P.
Published: (2021)

Untargeted serum metabolites profiling in high-fat diet mice supplemented with enhanced palm tocotrienol-rich fraction using UHPLC-MS
by: Goon D.E.; Ab-Rahim S.; Mohd Sakri A.H.; Mazlan M.; Tan J.K.; Abdul Aziz M.; Mohd Noor N.; Ibrahim E.; Sheikh Abdul Kadir S.H.
Published: (2021)

Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
by: Alias H.; Mohd Ranai N.; Lau S.C.D.; de Sonneville L.M.J.
Published: (2024)

Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
by: Alias, et al.
Published: (2024)

Whole-exome sequencing of ETV6/RUNX1 in four childhood acute lymphoblastic leukaemia cases
by: Zakaria Z.; Othman N.; Ismail A.; Kamaluddin N.R.; Esa E.; Rahman E.J.A.; Yusoff Y.M.; Fauzi F.M.; Keoh T.S.
Published: (2017)

LCMS/MS metabolite profiling and analysis of acute toxicity effect of the ethanolic extract of centella asiatica on zebrafish model
by: Zakaria F.; Ibrahim W.N.W.; Ismail I.S.; Ahmad H.; Manshoor N.; Ismail N.; Zainal Z.; Shaari K.
Published: (2019)

Differentiation of Ficus deltoidea varieties and chemical marker determination by UHPLC-TOFMS metabolomics for establishing quality control criteria of this popular Malaysian medicinal herb
by: Afzan A.; Kasim N.; Ismail N.H.; Azmi N.; Ali A.M.; Mat N.; Wolfender J.-L.
Published: (2019)

Discovery of Biomarkers for Myogenous Temporomandibular Disorders Through Salivary Metabolomic Profiling: A Pilot Study
by: Khoo, et al.
Published: (2023)

Discovery of Biomarkers for Myogenous Temporomandibular Disorders Through Salivary Metabolomic Profiling: A Pilot Study
by: Khoo S.C.; Shoji Y.; Teh C.H.; Ma N.L.
Published: (2023)

Antioxidant Enzyme Activities and Secondary Metabolite Profiling of Oil Palm Seedlings Treated with Combination of NPK Fertilizers Infected with Ganoderma boninense
by: Sahebi M.; Hanafi M.M.; Mohidin H.; Rafii M.Y.; Azizi P.; Idris A.S.; Fariz A.; Abiri R.; Taheri S.; Moradpoor M.
Published: (2018)

Persicaria minor ameliorates the cognitive function of chronic cerebral hypoperfusion rats: Metabolomic analysis and potential mechanisms
by: Chun L.W.; Ramachandran R.K.; Othman S.F.F.; Has A.T.C.; George A.; Mat N.H.; Suhaimi F.W.; Nor Hazalin N.A.M.; Hassan Z.
Published: (2023)

Centella asiatica (L.) Urb. Extract ameliorates branched-chain amino acid (BCAA) metabolism in acute reserpine-induced stress zebrafish model via 1H Nuclear Magnetic Resonance (NMR)-based metabolomics approach
by: Zakaria F.; Akhtar M.T.; Wan Norhamidah W.I.; Noraini A.B.; Muhamad A.; Shohaimi S.; Maulidiani; Ahmad H.; Ismail I.S.; Ismail N.H.; Shaari K.
Published: (2023)

The implication of the polymorphisms of COX-1, UGT1A6, and CYP2C9 among cardiovascular disease patients treated with aspirin
by: Abdul Jalil N.J.; Bannur Z.; Derahman A.; Maskon O.; Darinah N.; Hamidi H.; Ali O.; Gunasekaran; Rafizi M.; Azreen N.I.; Kek T.L.; Salleh M.Z.
Published: (2015)

ADSORPTION BEHAVIOUR OF P-NITROPHENOL IN AQUEOUS MEDIUM ON NON-TREATED SABA AND LADY FINGER BANANA PEELS
by: Bakar N.A.; Mahamod W.R.W.; Hashim N.; Juahir Y.; Harun A.; Ulianas A.
Published: (2022)

Urinary Metabolomics and Biochemical Analysis of Antihyperglycemic Effect of Ficus deltoidea Jack Varieties in Streptozotocin-Nicotinamide–Induced Diabetic Rats
by: Mohammad Noor H.S.; Ismail N.H.; Kasim N.; Mediani A.; Mohd Zohdi R.; Ali A.M.; Mat N.; Al-Mekhlafi N.A.
Published: (2020)

Fixed coefficient A(α) stable block backward differentiation formulas for stiff ordinary differential equations
by: Ibrahim Z.B.; Noor N.M.; Othman K.I.
Published: (2019)

Dietary Patterns, Metabolomic Profile, and Nutritype Signatures Associated with Type 2 Diabetes in Women with Postgestational Diabetes Mellitus: MyNutritype Study Protocol
by: Hasbullah F.Y.; Yusof B.-N.M.; Ghani R.A.; Daud Z.A.M.; Appannah G.; Abas F.; Shafie N.H.; Khir H.I.M.; Murphy H.R.
Published: (2022)

Metabolites alterations associated with obesity: A scoping review
by: Abdullah A.; Haron N.; Mohamed E.; Yusof M.I.M.; Shahril M.R.
Published: (2024)

Isolation, derivatization, and anti-microbial evaluation of secondary metabolites from Garcinia dryobalanoides
by: Zaine N.F.Z.; Zamakshshari N.H.; Abd Halim A.N.; Yi Mian V.J.; Ngui Sing N.
Published: (2024)

Composite backward differentiation formulas for solving stiff ordinary differential equation
by: Junaidi S.A.; Jaafar B.A.; Zawawi I.S.M.
Published: (2024)

The metabolites of Piper sarmentosum and their biological properties: a recent update
by: Adib, et al.
Published: (2024)

The metabolites of Piper sarmentosum and their biological properties: a recent update
by: Adib A.M.; Salmin N.N.; Kasim N.; Ling S.K.; Cordell G.A.; Ismail N.H.
Published: (2024)

Operational matrix for solving fractional differential equations with Erdelyi-Kober differential operator
by: Nasrudin F.S.M.; Phang C.; Mahadi S.; Arbin N.
Published: (2024)

Biological active metabolites from microalgae for healthcare and pharmaceutical industries: A comprehensive review
by: Ibrahim T.N.B.T.; Feisal N.A.S.; Kamaludin N.H.; Cheah W.Y.; How V.; Bhatnagar A.; Ma Z.; Show P.L.
Published: (2023)

Metabolite Biomarkers and Predictive Model Analysis for Patients with Type 2 Diabetes Mellitus With and Without Complications
by: Kek T.L.; Rofiee M.S.; Ghani R.A.; Nor N.A.M.; Salleh M.Z.
Published: (2023)

Coupling genotyping and computational modeling in prediction of antiepileptic drugs that cause Stevens Johnson syndrome and toxic epidermal Necrolysis for carrier of HLA-B*15:02
by: Teh L.K.; Selvaraj M.; Bannur Z.; Ismail M.I.M.; Rafia M.H.; Law W.C.; Sapuan S.; Puvanarajah S.; Ali P.S.S.; Salleh M.Z.
Published: (2016)

Correlation of chemical profiles obtained from 1H-NMR and LC–MS metabolomics with α-glucosidase inhibition activity for varietal selections of Ficus deltoidea
by: Kasim N.; Afzan A.; Mediani A.; Low K.H.; Ali A.M.; Mat N.; Wolfender J.-L.; Ismail N.H.
Published: (2022)

1H-NMR-based metabolomics to investigate the effects of Phoenix dactylifera seed extracts in LPS-IFN-γ-induced RAW 264.7 cells
by: Abdul-Hamid N.A.; Abas F.; Ismail I.S.; Tham C.L.; Maulidiani M.; Mediani A.; Swarup S.; Umashankar S.
Published: (2019)

Comparative study of acid-treated and alkali-treated carbonised Kapok-fibres for oil/water absorption system
by: Abdullah M.; Mohd Azlin Shah N.A.F.N.; Mohamed Saadun M.A.A.; Kadiran K.A.; Zaiton S.N.A.; Azman H.A.; Othman Z.S.; Osman M.S.
Published: (2019)

Factors associated with outcomes of severe acute necrotizing encephalopathy: A multicentre experience in Malaysia
by: Lee V.W.M.; Khoo T.B.; Teh C.M.; Heng H.S.; Li L.; Yusof Y.L.M.; Yahaya N.A.; Dharshini S.; Wong S.W.; Nickson T.; Mohamed A.R.; Fong C.Y.; Tan K.A.; Murugesu S.
Published: (2023)

Bacterial Secondary Metabolite Activation Through Epigenetic Modifiers: A Systematic Review
by: Rosli J.N.R.; Mohamad S.A.S.; Low A.L.M.; Ariffin S.
Published: (2024)

Pharmacogenomics based practice in Malaysia: The attitude, knowledge and adoption by the healthcare professionals
by: Bannur Z.; Bahaman S.; Salleh M.Z.; Kek T.L.
Published: (2014)

Potentially bioactive metabolites from pineapple waste extracts and their antioxidant and α-glucosidase inhibitory activities by 1H NMR
by: Azizan A.; Lee A.X.; Hamid N.A.A.; Maulidiani M.; Mediani A.; Ghafar S.Z.A.; Zolkeflee N.K.Z.; Abas F.
Published: (2020)

The acute toxicity of the metaldehyde on the climbing perch
by: Mohamad Ismail S.W.; Dahalan F.A.; Zakaria A.; Mad Shakaff A.Y.; Ahmad S.A.; Abd Shukor M.Y.; Sabullah M.K.; Abdul Khalil K.; Ab Jalil M.F.
Published: (2018)

Fucoidan extracts ameliorate acute colitis
by: Lean Q.Y.; Eri R.D.; Fitton J.H.; Patel R.P.; Gueven N.
Published: (2015)

CNN-Based Classification of Acute Myeloid Leukemia Blood Samples
by: Ahmad A.R.; Zainudin N.A.; Radzi M.D.I.M.; Halim N.H.A.; Osman M.K.; Saad Z.
Published: (2024)

Secondary metabolites from endemic species Iris adriatica Trinajstić ex Mitić (Iridaceae)
by: Bukvički D.; Novaković M.; Ab Ghani N.; Marin P.D.; Asakawa Y.
Published: (2018)