Potential antidiabetic activity of Plantago Major leaves extract in Streptozocin-induced diabetic rats

• Published in: Research Journal of Pharmaceutical, Biological and Chemical Sciences
• Main Author: Abdulghani M.A.; Hamid I.; Al-Naggar R.A.; Osman M.T.
• Format: Article
• Language: English
• Published: Research Journal of Pharmaceutical, Biological and Chemical Sciences 2014
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896517120&partnerID=40&md5=58636c17b3cd15e1990411d6131e9db2

Plantago major (PM) is one of a perennial plant and it belonging to the family of Plantaginaceae. It has been used in Malaysia as a folk remedy for diabetes and other illness. PM grows widely in whole of Europe and temperate Asia. The objective of study was evaluating antidiabetic activity of alcoholic extract of PM using STZ-induced diabetic rats. Methodology: adult male Sprague dually (SD) rats were used in the experiment for hypoglycaemic activity in oral glucose tolerance test (OGTT) and antidiabetic activity in streptozotocin induced rats. Results: showed that the continuous post-treatment for 14 days with the 1000 mg/kg of PM showed potential hypoglycaemic activity in OGTT and antidiabetic activity in streptozotocin induced rat models. Furthermore, isolation and establishment of exact mechanism of action of specific compound from PM is to be carried out in the future.