Synthesis of chitosan-gold nanoparticles for drug delivery

• Published in: Advanced Materials Research
• Main Author: Yazid H.; Yassin A.M.; Ruslan A.Z.; Alias S.H.; Adnan R.; Md Jani A.M.
• Format: Conference paper
• Language: English
• Published: Trans Tech Publications 2014
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896309863&doi=10.4028%2fwww.scientific.net%2fAMR.896.280&partnerID=40&md5=9e3b191264a574138a19616950963041

Gold nanoparticles (Au NPs) have potential applications in catalysis, drug delivery, sensors and environmental remediation. This wide range application is due to its amenability of synthesis and functionalization, less toxicity and ease of detection. The present work focuses on functionalization of Au NPs with chitosan for further application in biomedical research. Gold nanoparticles (Au NPs) functionalized chitosan were prepared by reducing gold salt solution at various pH medium in the presence of sodium borohydride. The effect of pH and chitosan concentration on the Au particle size and distribution are studied. The results revealed the dependence of Au particle size on the pH of the solution. The smallest Au particle size is found to form in a range of 10.22 ± 2.96 nm at 0.2% chitosan concentration. In this study, we anticipate the Au NPs functionalized chitosan can be used for drug delivery applications. © (2014) Trans Tech Publications, Switzerland.