Antioxidant properties of phenolic Schiff bases: Structure-activity relationship and mechanism of action

• Published in: Journal of Computer-Aided Molecular Design
• Main Author: Anouar E.H.; Raweh S.; Bayach I.; Taha M.; Baharudin M.S.; Di Meo F.; Hasan M.H.; Adam A.; Ismail N.H.; Weber J.-F.F.; Trouillas P.
• Format: Article
• Language: English
• Published: Kluwer Academic Publishers 2013
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84890856883&doi=10.1007%2fs10822-013-9692-0&partnerID=40&md5=8731ef74cbdc13d2a8d02de1b625ed88

Phenolic Schiff bases are known for their diverse biological activities and ability to scavenge free radicals. To elucidate (1) the structure-antioxidant activity relationship of a series of thirty synthetic derivatives of 2-methoxybezohydrazide phenolic Schiff bases and (2) to determine the major mechanism involved in free radical scavenging, we used density functional theory calculations (B3P86/6-31+(d,p)) within polarizable continuum model. The results showed the importance of the bond dissociation enthalpies (BDEs) related to the first and second (BDEd) hydrogen atom transfer (intrinsic parameters) for rationalizing the antioxidant activity. In addition to the number of OH groups, the presence of a bromine substituent plays an interesting role in modulating the antioxidant activity. Theoretical thermodynamic and kinetic studies demonstrated that the free radical scavenging by these Schiff bases mainly proceeds through proton-coupled electron transfer rather than sequential proton loss electron transfer, the latter mechanism being only feasible at relatively high pH. © 2013 Springer Science+Business Media Dordrecht.