Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats

Raised leptin levels have been reported in the placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unknown. This study investigates the effect of leptin administration on systolic blood pressure (SBP) and proteinuria...

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Published in:BioMed Research International
Main Author: Ibrahim H.S.; Omar E.; Froemming G.R.A.; Singh H.J.
Format: Article
Language:English
Published: 2013
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885630561&doi=10.1155%2f2013%2f298401&partnerID=40&md5=bd8a3c1419bc5769f86e6e7559f2038e
id 2-s2.0-84885630561
spelling 2-s2.0-84885630561
Ibrahim H.S.; Omar E.; Froemming G.R.A.; Singh H.J.
Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
2013
BioMed Research International
2013

10.1155/2013/298401
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885630561&doi=10.1155%2f2013%2f298401&partnerID=40&md5=bd8a3c1419bc5769f86e6e7559f2038e
Raised leptin levels have been reported in the placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unknown. This study investigates the effect of leptin administration on systolic blood pressure (SBP) and proteinuria and serum markers of endothelial activation during pregnancy in Sprague Dawley rats. From day 1 of pregnancy, 24 rats were randomised into those given either saline (group 1) or leptin at 60 or 120 g/kg/body weight/day (groups 2 and 3 resp.). SBP was measured every 5 days and 24-h urinary protein was measured at days 0 and 20 of pregnancy. Animals were euthanised on day 20 of pregnancy, and serum was collected for estimation of E-selectin and ICAM-1. Compared to group 1, SBP during the latter part of the pregnancy was significantly higher in the leptin-treated group (P<0.01). Urinary protein excretion, serum E-selectin, and ICAM-1 were significantly higher in leptin-treated rats (P<0.05). It seems that leptin administration to normotensive Sprague Dawley rats during pregnancy significantly increases SBP, urinary protein excretion, and markers of endothelial activation. However, further studies are required to examine the underlying mechanism responsible for this and its relevance to preeclampsia in humans. © 2013 Hisham Saleh Ibrahim et al.

23146141
English
Article
All Open Access; Gold Open Access
author Ibrahim H.S.; Omar E.; Froemming G.R.A.; Singh H.J.
spellingShingle Ibrahim H.S.; Omar E.; Froemming G.R.A.; Singh H.J.
Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
author_facet Ibrahim H.S.; Omar E.; Froemming G.R.A.; Singh H.J.
author_sort Ibrahim H.S.; Omar E.; Froemming G.R.A.; Singh H.J.
title Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
title_short Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
title_full Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
title_fullStr Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
title_full_unstemmed Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
title_sort Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats
publishDate 2013
container_title BioMed Research International
container_volume 2013
container_issue
doi_str_mv 10.1155/2013/298401
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885630561&doi=10.1155%2f2013%2f298401&partnerID=40&md5=bd8a3c1419bc5769f86e6e7559f2038e
description Raised leptin levels have been reported in the placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unknown. This study investigates the effect of leptin administration on systolic blood pressure (SBP) and proteinuria and serum markers of endothelial activation during pregnancy in Sprague Dawley rats. From day 1 of pregnancy, 24 rats were randomised into those given either saline (group 1) or leptin at 60 or 120 g/kg/body weight/day (groups 2 and 3 resp.). SBP was measured every 5 days and 24-h urinary protein was measured at days 0 and 20 of pregnancy. Animals were euthanised on day 20 of pregnancy, and serum was collected for estimation of E-selectin and ICAM-1. Compared to group 1, SBP during the latter part of the pregnancy was significantly higher in the leptin-treated group (P<0.01). Urinary protein excretion, serum E-selectin, and ICAM-1 were significantly higher in leptin-treated rats (P<0.05). It seems that leptin administration to normotensive Sprague Dawley rats during pregnancy significantly increases SBP, urinary protein excretion, and markers of endothelial activation. However, further studies are required to examine the underlying mechanism responsible for this and its relevance to preeclampsia in humans. © 2013 Hisham Saleh Ibrahim et al.
publisher
issn 23146141
language English
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accesstype All Open Access; Gold Open Access
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