Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones

2,4-Dimethylbenzoylhydrazones 1-30 were synthesized by condensation reactions of 2,4-dimethylbenzoylhydrazide with various aromatic aldehydes and characterized. The assigned structures of compounds 10, 15 and 22 were further supported by single-crystal X-ray diffraction data. The synthesized compoun...

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Published in:Molecules
Main Author: Taha M.; Ismail N.H.; Jamil W.; Yousuf S.; Jaafar F.M.; Ali M.I.; Kashif S.M.; Hussain E.
Format: Article
Language:English
Published: 2013
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885126789&doi=10.3390%2fmolecules180910912&partnerID=40&md5=29310a538df4b839aed411a6e07db04d
id 2-s2.0-84885126789
spelling 2-s2.0-84885126789
Taha M.; Ismail N.H.; Jamil W.; Yousuf S.; Jaafar F.M.; Ali M.I.; Kashif S.M.; Hussain E.
Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
2013
Molecules
18
9
10.3390/molecules180910912
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885126789&doi=10.3390%2fmolecules180910912&partnerID=40&md5=29310a538df4b839aed411a6e07db04d
2,4-Dimethylbenzoylhydrazones 1-30 were synthesized by condensation reactions of 2,4-dimethylbenzoylhydrazide with various aromatic aldehydes and characterized. The assigned structures of compounds 10, 15 and 22 were further supported by single-crystal X-ray diffraction data. The synthesized compounds were evaluated for their in vitro DPPH radical scavenging activity. They exerted varying degree of scavenging activity toward DPPH radical with IC50 values between 25.6-190 μM. Compounds 1, 4, 2, 3, 7, and 6 have IC50 values of 25.6, 28.1, 29.3, 29.8, 30.0 and 30.1 μM respectively, showing better activity than an n-propyl gallate standard (IC50 value = 30.30 μM). For super oxide anion scavenging activity compounds 1, 2 and 3 with IC50 values of 98.3, 102.6, and 105.6, respectively, also showed better activity than the n-propyl gallate standard (IC50 value = 106.34 μM). © 2013 by the authors.

14203049
English
Article
All Open Access; Gold Open Access
author Taha M.; Ismail N.H.; Jamil W.; Yousuf S.; Jaafar F.M.; Ali M.I.; Kashif S.M.; Hussain E.
spellingShingle Taha M.; Ismail N.H.; Jamil W.; Yousuf S.; Jaafar F.M.; Ali M.I.; Kashif S.M.; Hussain E.
Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
author_facet Taha M.; Ismail N.H.; Jamil W.; Yousuf S.; Jaafar F.M.; Ali M.I.; Kashif S.M.; Hussain E.
author_sort Taha M.; Ismail N.H.; Jamil W.; Yousuf S.; Jaafar F.M.; Ali M.I.; Kashif S.M.; Hussain E.
title Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
title_short Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
title_full Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
title_fullStr Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
title_full_unstemmed Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
title_sort Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones
publishDate 2013
container_title Molecules
container_volume 18
container_issue 9
doi_str_mv 10.3390/molecules180910912
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885126789&doi=10.3390%2fmolecules180910912&partnerID=40&md5=29310a538df4b839aed411a6e07db04d
description 2,4-Dimethylbenzoylhydrazones 1-30 were synthesized by condensation reactions of 2,4-dimethylbenzoylhydrazide with various aromatic aldehydes and characterized. The assigned structures of compounds 10, 15 and 22 were further supported by single-crystal X-ray diffraction data. The synthesized compounds were evaluated for their in vitro DPPH radical scavenging activity. They exerted varying degree of scavenging activity toward DPPH radical with IC50 values between 25.6-190 μM. Compounds 1, 4, 2, 3, 7, and 6 have IC50 values of 25.6, 28.1, 29.3, 29.8, 30.0 and 30.1 μM respectively, showing better activity than an n-propyl gallate standard (IC50 value = 30.30 μM). For super oxide anion scavenging activity compounds 1, 2 and 3 with IC50 values of 98.3, 102.6, and 105.6, respectively, also showed better activity than the n-propyl gallate standard (IC50 value = 106.34 μM). © 2013 by the authors.
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issn 14203049
language English
format Article
accesstype All Open Access; Gold Open Access
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