Acylhydrazide schiff bases: Synthesis and antiglycation activity

QR Code

Acylhydrazide schiff bases: Synthesis and antiglycation activity

Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 μM), 27 (IC50 = 234.83 ± 10.28 μM), 2 (IC50 = 240.99 ± 4.2 μM), and 14 (IC50 = 276.2 ± 2.3 μM) showed antiglycation potential comparable to the standard rutin...

Full description

Bibliographic Details
Published in:	Journal of the Chemical Society of Pakistan
Main Author:	Khan K.M.; Taha M.; Rahim F.; Fakhri M.I.; Jamil W.; Khan M.; Rasheed S.; Karim A.; Perveen S.; Choudhary M.I.
Format:	Article
Language:	English
Published:	2013
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879727205&partnerID=40&md5=8a5fa6595cc3ce6d806bf70c4b71c2ba

Similar Items

Synthesis of 4-methoxybenzoylhydrazones and evaluation of their antiglycation activity
by: Taha M.; Naz H.; Rasheed S.; Ismail N.H.; Rahman A.A.; Yousuf S.; Choudhary M.I.
Published: (2014)

Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones
by: Khan K.M.; Saad S.M.; Shaikh N.N.; Hussain S.; Fakhri M.I.; Perveen S.; Taha M.; Choudhary M.I.
Published: (2014)

Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton
by: Khan K.M.; Rahim F.; Wadood A.; Kosar N.; Taha M.; Lalani S.; Khan A.; Fakhri M.I.; Junaid M.; Rehman W.; Khan M.; Perveen S.; Sajid M.; Choudhary M.I.
Published: (2014)

Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease
by: Khan K.M.; Rahim F.; Khan A.; Shabeer M.; Hussain S.; Rehman W.; Taha M.; Khan M.; Perveen S.; Choudhary M.I.
Published: (2014)

Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
by: Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
Published: (2015)

New facile, eco-friendly and rapid synthesis of trisubstituted alkenes using bismuth nitrate as lewis acid
by: Muhammad M.T.; Khan K.M.; Taha M.; Khan T.; Hussain S.; Fakhri M.I.; Perveen S.; Voelter W.
Published: (2016)

Evaluation of bisindole as potent β-glucuronidase inhibitors: Synthesis and in silico based studies
by: Khan K.M.; Rahim F.; Wadood A.; Taha M.; Khan M.; Naureen S.; Ambreen N.; Hussain S.; Perveen S.; Choudhary M.I.
Published: (2014)

2-(2′-Pyridyl) benzimidazole derivatives and their urease inhibitory activity
by: Saify Z.S.; Kamil A.; Akhtar S.; Taha M.; Khan A.; Khan K.M.; Jahan S.; Rahim F.; Perveen S.; Choudhary M.I.
Published: (2014)

Anti-cancer potential of benzophenone-bis-Schiff bases on human pancreatic cancer cell line
by: Khan K.M.; Rasheed H.; Fatima B.; Hayat M.; Rahim F.; Ullah H.; Hameed A.; Taha M.; Tahir A.; Perveen S.
Published: (2016)

Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
by: Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
Published: (2013)

Synthesis of benzimidazole derivatives and their antiglycation, antioxidant, antiurease and molecular docking study
by: Taha M.; Rahim F.; Adalath B.; Imran S.; Mohammed Khan K.; Adnan Ali shah S.; Uddin N.; Nawaz M.; Break M.K.B.; Magam S.M.; Alqarni S.
Published: (2024)

Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity
by: Imran S.; Taha M.; Ismail N.H.; Khan K.M.; Naz F.; Hussain M.; Tauseef S.
Published: (2014)

Carbohydrazones as new class of carbonic anhydrase inhibitors: Synthesis, kinetics, and ligand docking studies
by: Iqbal S.; Saleem M.; Azim M.K.; Taha M.; Salar U.; Khan K.M.; Perveen S.; Choudhary M.I.
Published: (2017)

Synthesis of benzimidazole derivatives and their antiglycation, antioxidant, antiurease and molecular docking study
by: Taha, et al.
Published: (2024)

Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones
by: Taha M.; Alkadi K.A.A.; Ismail N.H.; Imran S.; Adam A.; Kashif S.M.; Shah S.A.A.; Jamil W.; Sidiqqui S.; Khan K.M.
Published: (2019)

Synthesis and antiurease & antioxidant activities of bis-Schiff bases of isophthalaldehyde
by: Rahim F.; Waseeq-Ur-Rehamn; Shehzad M.; Khan A.; Taha M.; Abid O.U.R.; Quereshi M.T.; Tauseef I.; Rehman W.
Published: (2016)

Synthesis, in vitro thymidine phosphorylase inhibitory activity and molecular docking study of novel pyridine-derived bis-oxadiazole bearing bis-schiff base derivatives
by: Hussain R.; Rehman W.; Rahim F.; Khan S.; Alanazi A.S.; Alanazi M.M.; Rasheed L.; Khan Y.; Adnan. Ali. Shah S.; Taha M.
Published: (2023)

Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
by: Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
Published: (2016)

Synthesis, anti-diabetic and in silico QSAR analysis of flavone hydrazide Schiff base derivatives
by: Jamil W.; Shaikh J.; Yousuf M.; Taha M.; Khan K.M.; Shah S.A.A.
Published: (2022)

Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents
by: Taha M.; Sain A.A.; Ali M.; Anouar E.H.; Rahim F.; Ismail N.H.; Adenan M.I.; Imran S.; Al-Harrasi A.; Nawaz F.; Iqbal N.; Khan K.M.
Published: (2020)

Aryl-oxadiazole Schiff bases: Synthesis, α-glucosidase in vitro inhibitory activity and their in silico studies
by: Ullah H.; Rahim F.; Taha M.; Hussain R.; Tabassum N.; Wadood A.; Nawaz M.; Mosaddik A.; Imran S.; Wahab Z.; Miana G.A.; Kanwal; Khan K.M.
Published: (2020)

Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies
by: Imran S.; Taha M.; Ismail N.H.; Fayyaz S.; Khan K.M.; Choudhary M.I.
Published: (2016)

Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor
by: Imran S.; Taha M.; Ismail N.H.; Fayyaz S.; Khan K.M.; Choudhary M.I.
Published: (2015)

Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases
by: Rahim F.; Ullah H.; Taha M.; Wadood A.; Javed M.T.; Rehman W.; Nawaz M.; Ashraf M.; Ali M.; Sajid M.; Ali F.; Khan M.N.; Khan K.M.
Published: (2016)

Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential
by: Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Published: (2015)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
by: Rahim F.; Malik F.; Ullah H.; Wadood A.; Khan F.; Javid M.T.; Taha M.; Rehman W.; Ur Rehman A.; Khan K.M.
Published: (2015)

Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
by: Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
Published: (2014)

Synthesis of Benzofuran–based Schiff bases as anti-diabetic compounds and their molecular docking studies
by: Adalat B.; Rahim F.; Taha M.; Hayat S.; Iqbal N.; Ali Z.; Shah S.A.A.; Wadood A.; Rehman A.U.; Khan K.M.
Published: (2022)

Erratum: Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential (Medicinal Chemistry Research (DOI 10.1007/s00044-014-1213-8))
by: Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Published: (2015)

2-(2'-pyridyl) benzimidazole analogs and their ß-glucuronidase inhibitory activity
by: Kamil A.; Akhtar S.; Noureen S.; Saify Z.S.; Jahan S.; Khan K.M.; Rahim F.; Taha M.; Mushtaq N.; Arif M.; Perveen S.; Chaudhary M.I.
Published: (2015)

Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
by: Taha M.; Ismail N.H.; Lalani S.; Fatmi M.Q.; Atia-Tul-Wahab; Siddiqui S.; Khan K.M.; Imran S.; Choudhary M.I.
Published: (2015)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: Taha M.; Gilani S.J.; Kazmi I.; Rahim F.; Adalat B.; Ullah H.; Nawaz F.; Wadood A.; Ali Z.; Shah S.A.A.; Khan K.M.
Published: (2024)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar A.; Khan I.U.; Nabi M.; Ullah H.; Iqbal N.; Zeb B.; Hussain A.; Khan D.; Rab A.; Junaid S.M.; Taha M.; Shah S.A.A.; Rahim F.
Published: (2024)

Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro α-glucosidase inhibitory activity, and in silico studies
by: Ali F.; Khan K.M.; Salar U.; Taha M.; Ismail N.H.; Wadood A.; Riaz M.; Perveen S.
Published: (2017)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
by: Rahim F.; Zaman K.; Taha M.; Ullah H.; Ghufran M.; Wadood A.; Rehman W.; Uddin N.; Shah S.A.A.; Sajid M.; Nawaz F.; Khan K.M.
Published: (2020)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar, et al.
Published: (2024)

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
by: Khan K.M.; Qurban S.; Salar U.; Taha M.; Hussain S.; Perveen S.; Hameed A.; Ismail N.H.; Riaz M.; Wadood A.
Published: (2016)

Synthesis of 3,4,5-trihydroxybenzohydrazone and evaluation of their urease inhibition potential
by: Taha M.; Shah S.A.A.; Khan A.; Arshad F.; Ismail N.H.; Afifi M.; Imran S.; Choudhary M.I.
Published: (2019)

Synthesis and molecular modelling studies of phenyl linked oxadiazole-phenylhydrazone hybrids as potent antileishmanial agents
by: Taha M.; Ismail N.H.; Imran S.; Anouar E.H.; Selvaraj M.; Jamil W.; Ali M.; Kashif S.M.; Rahim F.; Khan K.M.; Adenan M.I.
Published: (2017)

Synthesis, in vitro β-glucuronidase inhibitory activity and in silico studies of novel (E)-4-Aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazoles
by: Salar U.; Khan K.M.; Syed S.; Taha M.; Ali F.; Ismail N.H.; Perveen S.; Wadood A.; Ghufran M.
Published: (2017)