Acylhydrazide schiff bases: Synthesis and antiglycation activity
Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 μM), 27 (IC50 = 234.83 ± 10.28 μM), 2 (IC50 = 240.99 ± 4.2 μM), and 14 (IC50 = 276.2 ± 2.3 μM) showed antiglycation potential comparable to the standard rutin...
| Published in: | Journal of the Chemical Society of Pakistan |
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| Format: | Article |
| Language: | English |
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2013
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879727205&partnerID=40&md5=8a5fa6595cc3ce6d806bf70c4b71c2ba |
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2-s2.0-84879727205 Khan K.M.; Taha M.; Rahim F.; Fakhri M.I.; Jamil W.; Khan M.; Rasheed S.; Karim A.; Perveen S.; Choudhary M.I. Acylhydrazide schiff bases: Synthesis and antiglycation activity 2013 Journal of the Chemical Society of Pakistan 35 3 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879727205&partnerID=40&md5=8a5fa6595cc3ce6d806bf70c4b71c2ba Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 μM), 27 (IC50 = 234.83 ± 10.28 μM), 2 (IC50 = 240.99 ± 4.2 μM), and 14 (IC50 = 276.2 ± 2.3 μM) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 ± 1.5 μM). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques. 2535106 English Article |
| author |
Khan K.M.; Taha M.; Rahim F.; Fakhri M.I.; Jamil W.; Khan M.; Rasheed S.; Karim A.; Perveen S.; Choudhary M.I. |
| spellingShingle |
Khan K.M.; Taha M.; Rahim F.; Fakhri M.I.; Jamil W.; Khan M.; Rasheed S.; Karim A.; Perveen S.; Choudhary M.I. Acylhydrazide schiff bases: Synthesis and antiglycation activity |
| author_facet |
Khan K.M.; Taha M.; Rahim F.; Fakhri M.I.; Jamil W.; Khan M.; Rasheed S.; Karim A.; Perveen S.; Choudhary M.I. |
| author_sort |
Khan K.M.; Taha M.; Rahim F.; Fakhri M.I.; Jamil W.; Khan M.; Rasheed S.; Karim A.; Perveen S.; Choudhary M.I. |
| title |
Acylhydrazide schiff bases: Synthesis and antiglycation activity |
| title_short |
Acylhydrazide schiff bases: Synthesis and antiglycation activity |
| title_full |
Acylhydrazide schiff bases: Synthesis and antiglycation activity |
| title_fullStr |
Acylhydrazide schiff bases: Synthesis and antiglycation activity |
| title_full_unstemmed |
Acylhydrazide schiff bases: Synthesis and antiglycation activity |
| title_sort |
Acylhydrazide schiff bases: Synthesis and antiglycation activity |
| publishDate |
2013 |
| container_title |
Journal of the Chemical Society of Pakistan |
| container_volume |
35 |
| container_issue |
3 |
| doi_str_mv |
|
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879727205&partnerID=40&md5=8a5fa6595cc3ce6d806bf70c4b71c2ba |
| description |
Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 μM), 27 (IC50 = 234.83 ± 10.28 μM), 2 (IC50 = 240.99 ± 4.2 μM), and 14 (IC50 = 276.2 ± 2.3 μM) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 ± 1.5 μM). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques. |
| publisher |
|
| issn |
2535106 |
| language |
English |
| format |
Article |
| accesstype |
|
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1809678488427298816 |