Methanol extract of bauhinia purpurea leaf possesses anti-ulcer activity

• Published in: Medical Principles and Practice
• Main Author: Zakaria Z.A.; Abdul Hisam E.E.; Norhafizah M.; Rofiee M.S.; Othman F.; Hasiah A.H.; Vasudevan M.
• Format: Article
• Language: English
• Published: 2012
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865010508&doi=10.1159%2f000336593&partnerID=40&md5=9d068885e22d6aad52ac0f7d43413aac

Objective: The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP). Materials and Methods: MEBP was administered at doses of 100, 500 and 1,000 mg/kg and its effects on acute toxicity, absolute ethanol-and indomethacin-induced gastric ulceration, and pyloric ligation tests in rats were investigated. Results: At a dose of 5,000 mg/kg, MEBP did not cause any signs of toxicity in rats when given orally. Oral administration of MEBP exerted anti-ulcer activity (p < 0.05) in all models tested. However, a dose-dependent protection was observed only in the indomethacin-induced gastric ulceration model. Histological studies supported the observed anti-ulcer activity of MEBP. In the pyloric ligation assay, MEBP significantly increased gastric wall mucus secretion (p < 0.05), but did not affect the acidity of the gastric contents. Conclusion: MEBP exhibited anti-ulcer activity, which could be due to the presence of flavonoids, saponins or other polyphenols, thereby validating the traditional use of B. purpurea in the treatment of ulcers. Copyright © 2012 S. Karger AG, Basel.