Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously

• Published in: Applied Clay Science
• Main Author: Hussein M.Z.; Rahman N.S.S.A.; Sarijo S.H.; Zainal Z.
• Format: Article
• Language: English
• Published: 2012
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84858750909&doi=10.1016%2fj.clay.2012.01.012&partnerID=40&md5=bf0ec865ef7134dccb9632a9c02c86a5

A new monophasic nanohybrid containing two phenoxyherbicides anions, 4-(2,4-dichlorophenoxy)butyrate (DPBA) and 2-(3-chlorophenoxy)propionate (CPPA), was successfully synthesized. The two anions were simultaneously intercalated into the inorganic interlayers of zinc-aluminum-layered double hydroxide (ZAL) for the formation of a nanohybrid, ZAL-CPPA-DPBA (NCDX) by an anion-exchange method. Powder X-ray diffraction, direct-injection mass spectrometry and Fourier transform infrared spectroscopy studies confirmed the dual intercalation of both anions into the host interlayer regions. The well-ordered, layered nanohybrid was synthesized using 0.1. M solution of both anions. The basal spacing expanded from 8.9. Å in ZAL to 27.43. Å in the nanohybrid. The release of both anions from the nanohybrid into an aqueous solution of 0.001. M sodium carbonate was found to be governed by pseudo second-order kinetics. This release demonstrates the potential application of layered materials as reservoirs and delivery system, especially when multiple active agents are used simultaneously in the formation of an organic-inorganic host-guest nanohybrid with controlled-release properties. © 2012 Elsevier B.V.