Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine

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Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine

What is known and Objective: Genetic polymorphisms of thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA 94C>A) contribute to variable responses, including fatal adverse effects, among subjects treated with 6-mercaptopurine (6-MP). Our objectives were to inv...

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Bibliographic Details
Published in:	Journal of Clinical Pharmacy and Therapeutics
Main Author:	Wan Rosalina W.R.; Teh L.K.; Mohamad N.; Nasir A.; Yusoff R.; Baba A.A.; Salleh M.Z.
Format:	Article
Language:	English
Published:	2012
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857999606&doi=10.1111%2fj.1365-2710.2011.01272.x&partnerID=40&md5=e5870a39360d302f6016c584fde28119

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