The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in a...

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Published in:Journal of Chemical Crystallography
Main Author: Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.
Format: Article
Language:English
Published: 2011
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855829387&doi=10.1007%2fs10870-011-0190-8&partnerID=40&md5=72eeddd08e1c7851430e907a6a78e2eb
id 2-s2.0-84855829387
spelling 2-s2.0-84855829387
Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.
The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
2011
Journal of Chemical Crystallography
41
12
10.1007/s10870-011-0190-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855829387&doi=10.1007%2fs10870-011-0190-8&partnerID=40&md5=72eeddd08e1c7851430e907a6a78e2eb
Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC 50 value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA) 2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. © Springer Science+Business Media, LLC 2011.

10741542
English
Article
author Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.
spellingShingle Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.
The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
author_facet Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.
author_sort Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.
title The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
title_short The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
title_full The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
title_fullStr The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
title_full_unstemmed The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
title_sort The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin
publishDate 2011
container_title Journal of Chemical Crystallography
container_volume 41
container_issue 12
doi_str_mv 10.1007/s10870-011-0190-8
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855829387&doi=10.1007%2fs10870-011-0190-8&partnerID=40&md5=72eeddd08e1c7851430e907a6a78e2eb
description Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC 50 value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA) 2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. © Springer Science+Business Media, LLC 2011.
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issn 10741542
language English
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