The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

• Published in: Journal of Chemical Crystallography
• Main Author: Manan M.A.F.A.; Tahir M.I.M.; Crouse K.A.; Rosli R.; How F.N.-F.; Watkin D.J.
• Format: Article
• Language: English
• Published: 2011
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855829387&doi=10.1007%2fs10870-011-0190-8&partnerID=40&md5=72eeddd08e1c7851430e907a6a78e2eb
• ISSN: 10741542
• DOI: 10.1007/s10870-011-0190-8

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC 50 value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA) 2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. © Springer Science+Business Media, LLC 2011.