Preliminary analysis of the antinociceptive activity of zerumbone
We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive ef...
| Published in: | Fitoterapia |
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| Format: | Article |
| Language: | English |
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2009
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349257429&doi=10.1016%2fj.fitote.2009.02.002&partnerID=40&md5=b3ee87816ffcff77aed7e4c91ee192ef |
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2-s2.0-67349257429 |
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2-s2.0-67349257429 Sulaiman M.R.; Perimal E.K.; Zakaria Z.A.; Mokhtar F.; Akhtar M.N.; Lajis N.H.; Israf D.A. Preliminary analysis of the antinociceptive activity of zerumbone 2009 Fitoterapia 80 4 10.1016/j.fitote.2009.02.002 https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349257429&doi=10.1016%2fj.fitote.2009.02.002&partnerID=40&md5=b3ee87816ffcff77aed7e4c91ee192ef We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action. © 2009 Elsevier B.V. All rights reserved. 0367326X English Article |
| author |
Sulaiman M.R.; Perimal E.K.; Zakaria Z.A.; Mokhtar F.; Akhtar M.N.; Lajis N.H.; Israf D.A. |
| spellingShingle |
Sulaiman M.R.; Perimal E.K.; Zakaria Z.A.; Mokhtar F.; Akhtar M.N.; Lajis N.H.; Israf D.A. Preliminary analysis of the antinociceptive activity of zerumbone |
| author_facet |
Sulaiman M.R.; Perimal E.K.; Zakaria Z.A.; Mokhtar F.; Akhtar M.N.; Lajis N.H.; Israf D.A. |
| author_sort |
Sulaiman M.R.; Perimal E.K.; Zakaria Z.A.; Mokhtar F.; Akhtar M.N.; Lajis N.H.; Israf D.A. |
| title |
Preliminary analysis of the antinociceptive activity of zerumbone |
| title_short |
Preliminary analysis of the antinociceptive activity of zerumbone |
| title_full |
Preliminary analysis of the antinociceptive activity of zerumbone |
| title_fullStr |
Preliminary analysis of the antinociceptive activity of zerumbone |
| title_full_unstemmed |
Preliminary analysis of the antinociceptive activity of zerumbone |
| title_sort |
Preliminary analysis of the antinociceptive activity of zerumbone |
| publishDate |
2009 |
| container_title |
Fitoterapia |
| container_volume |
80 |
| container_issue |
4 |
| doi_str_mv |
10.1016/j.fitote.2009.02.002 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349257429&doi=10.1016%2fj.fitote.2009.02.002&partnerID=40&md5=b3ee87816ffcff77aed7e4c91ee192ef |
| description |
We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action. © 2009 Elsevier B.V. All rights reserved. |
| publisher |
|
| issn |
0367326X |
| language |
English |
| format |
Article |
| accesstype |
|
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1814778510624948224 |