Preliminary analysis of the antinociceptive activity of zerumbone
We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive ef...
| Published in: | Fitoterapia |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
2009
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349257429&doi=10.1016%2fj.fitote.2009.02.002&partnerID=40&md5=b3ee87816ffcff77aed7e4c91ee192ef |
| Summary: | We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action. © 2009 Elsevier B.V. All rights reserved. |
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| ISSN: | 0367326X |
| DOI: | 10.1016/j.fitote.2009.02.002 |