Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models

• Published in: Journal of Natural Medicines
• Main Author: Zakaria Z.A.; Abdul Ghani Z.D.F.; Raden Mohd. Nor R.N.S.; Gopalan H.K.; Sulaiman M.R.; Mat Jais A.M.; Somchit M.N.; Kader A.A.; Ripin J.
• Format: Article
• Language: English
• Published: Springer Japan 2008
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-40549105769&doi=10.1007%2fs11418-007-0224-x&partnerID=40&md5=75a678ff57bdef1ca9228925c74a2497

This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever. © 2008 The Japanese Society of Pharmacognosy and Springer.