Interactive mixture as a rapid drug delivery system
The effectiveness of an interactive mixture as a rapid drug delivery system is compared with that of a solid dispersion. The influences of drug load, particle size, and crystallinity of these test systems are investigated. The interactive mixtures and solid dispersions were prepared from polyethylen...
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2-s2.0-39849089589 Lee C.C.; Ong C.L.C.; Heng P.W.S.; Chan L.W.; Wong T.W. Interactive mixture as a rapid drug delivery system 2008 Drug Development and Industrial Pharmacy 34 2 10.1080/03639040701542291 https://www.scopus.com/inward/record.uri?eid=2-s2.0-39849089589&doi=10.1080%2f03639040701542291&partnerID=40&md5=6fa86ba64ade78dc104a7c9e8ca48576 The effectiveness of an interactive mixture as a rapid drug delivery system is compared with that of a solid dispersion. The influences of drug load, particle size, and crystallinity of these test systems are investigated. The interactive mixtures and solid dispersions were prepared from polyethylene glycol (PEG) 3350 and hydrophobic nifedipine drug by means of physical mixing and melting methods, respectively. The formed products were subjected to drug particle size and crystallinity analyses, and dissolution tests. In comparison with the interactive mixtures, the solid dispersions with low drug load were more effective as a rapid drug delivery system, as the size of a given batch of drug particles was markedly reduced by the molten PEG 3350. The rate and extent of drug dissolution were mainly promoted by decreasing effective drug particle size. However, these were lower in the solid dispersions than in the interactive mixtures when a high load of fine drug particles was used as the starting material. This was attributed to drug coarsening during the preparation of the solid dispersion. Unlike solid dispersions, the interactive mixtures could accommodate a high load of fine drug particles without compromising its capacity to enhance the rate and extent of drug dissolution. The interactive mixture is appropriate for use to deliver a fine hydrophobic drug in a formulation requiring a high drug load. Copyright © Informa Healthcare USA, Inc. 15205762 English Article |
author |
Lee C.C.; Ong C.L.C.; Heng P.W.S.; Chan L.W.; Wong T.W. |
spellingShingle |
Lee C.C.; Ong C.L.C.; Heng P.W.S.; Chan L.W.; Wong T.W. Interactive mixture as a rapid drug delivery system |
author_facet |
Lee C.C.; Ong C.L.C.; Heng P.W.S.; Chan L.W.; Wong T.W. |
author_sort |
Lee C.C.; Ong C.L.C.; Heng P.W.S.; Chan L.W.; Wong T.W. |
title |
Interactive mixture as a rapid drug delivery system |
title_short |
Interactive mixture as a rapid drug delivery system |
title_full |
Interactive mixture as a rapid drug delivery system |
title_fullStr |
Interactive mixture as a rapid drug delivery system |
title_full_unstemmed |
Interactive mixture as a rapid drug delivery system |
title_sort |
Interactive mixture as a rapid drug delivery system |
publishDate |
2008 |
container_title |
Drug Development and Industrial Pharmacy |
container_volume |
34 |
container_issue |
2 |
doi_str_mv |
10.1080/03639040701542291 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-39849089589&doi=10.1080%2f03639040701542291&partnerID=40&md5=6fa86ba64ade78dc104a7c9e8ca48576 |
description |
The effectiveness of an interactive mixture as a rapid drug delivery system is compared with that of a solid dispersion. The influences of drug load, particle size, and crystallinity of these test systems are investigated. The interactive mixtures and solid dispersions were prepared from polyethylene glycol (PEG) 3350 and hydrophobic nifedipine drug by means of physical mixing and melting methods, respectively. The formed products were subjected to drug particle size and crystallinity analyses, and dissolution tests. In comparison with the interactive mixtures, the solid dispersions with low drug load were more effective as a rapid drug delivery system, as the size of a given batch of drug particles was markedly reduced by the molten PEG 3350. The rate and extent of drug dissolution were mainly promoted by decreasing effective drug particle size. However, these were lower in the solid dispersions than in the interactive mixtures when a high load of fine drug particles was used as the starting material. This was attributed to drug coarsening during the preparation of the solid dispersion. Unlike solid dispersions, the interactive mixtures could accommodate a high load of fine drug particles without compromising its capacity to enhance the rate and extent of drug dissolution. The interactive mixture is appropriate for use to deliver a fine hydrophobic drug in a formulation requiring a high drug load. Copyright © Informa Healthcare USA, Inc. |
publisher |
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issn |
15205762 |
language |
English |
format |
Article |
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record_format |
scopus |
collection |
Scopus |
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1809677914895024128 |